Triphasic waves on EEG: GPDs with triphasic morphology

Triphasic waves · Periodic · ICU

Frontally predominant triphasic complexes at about 1.6 Hz, arriving later posteriorly. Simulated trace, longitudinal bipolar channels. Open in the interactive viewer

What it looks like

Three phases, the second (positive) the largest: negative–positive–negative. Frontally predominant at 1.5–2.5 Hz, often with an anterior-to-posterior lag, increasing with stimulation. ACNS treats "triphasic morphology" as a modifier of GPDs. 1

What it means at the bedside

Classically hepatic or uraemic encephalopathy, also sepsis and drug toxicity (cefepime, lithium, baclofen). They are not specific: expert agreement on triphasic morphology is only fair, and it does not exclude an association with seizures. 22 Attenuation with a benzodiazepine without clinical improvement proves nothing.

PeriodicFrontalOften metabolic

Sources

  1. Hirsch LJ, et al. American Clinical Neurophysiology Society's Standardized Critical Care EEG Terminology: 2021 version. J Clin Neurophysiol 2021;38:1–29. doi.org/10.1097/WNP.0000000000000806
  2. Foreman B, et al. Generalized periodic discharges and 'triphasic waves': a blinded evaluation of inter-rater agreement and clinical significance. Clin Neurophysiol 2016;127:1073–1080. pubmed.ncbi.nlm.nih.gov/26294138/

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