3 Hz spike-and-wave on EEG: absence seizures

Generalized spike-wave discharge · Epileptiform

Generalized 3 Hz spike-and-wave for eight seconds, abrupt on and off, with a stare. Simulated trace, longitudinal bipolar channels. Open in the interactive viewer

What it looks like

Bilaterally synchronous, frontally maximal spike-and-wave complexes at about 3 Hz, starting and stopping abruptly on a normal background, often slowing slightly towards the end. The signature of typical absence seizures. 23

What it means at the bedside

In childhood absence epilepsy, hyperventilation for three minutes brings on a seizure in most untreated children. Ethosuximide is the first-line treatment when absences are the only seizure type. 18,23

EpileptiformGeneralizedAbsence

Sources

  1. Glauser TA, et al. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. N Engl J Med 2010;362:790–799. doi.org/10.1056/NEJMoa0902014
  2. Specchio N, et al. ILAE classification and definition of epilepsy syndromes with onset in childhood. Epilepsia 2022;63:1398–1442. doi.org/10.1111/epi.17241

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